Therapeutic potential of D prostanoid receptor 1 signal enhancement in a murine model of food allergy
Tatsuro Nakamura, Rina Hirai, Yuri Tachibana, Sakura Masuko, Nanae Nagata, Takahisa Murata.
Mast cells play a key role in the development of antigen-induced food allergies. Activated mast cells release several inflammatory mediators that induce local intestinal inflammation and lead to systemic allergy symptoms. This intestinal inflammation stimulates infiltration of mucosal mast cells (MMCs) into the intestinal tract, resulting in expansion of intestinal mast cells. Furthermore, patients with food allergies possess greater numbers of intestinal mast cells than those without food allergies.
- : The Journal of Allergy and Clinical Immunology
- : 10.1016/j.jaci.2019.01.039
- : https://www.jacionline.org/article/S0091-6749(19)30199-X/abstract