Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations.
Maki Igarashi, Shun Nogawa, Kaoru Kawafune, Tsuyoshi Hachiya, Shoko Takahashi, Huijuan Jia, Kenji Saito, Hisanori Kato*
We conducted a meta-analysis of a GWAS including 12,603 Japanese individuals and identified a susceptibility locus for fish intake frequency at 12q24 (lead variant was rs11066015, P = 5.4 × 10-11). rs11066015 was in a strong linkage disequilibrium with rs671, a well-known SNP related to alcohol metabolism. When adjusted for alcohol drinking, the association between rs11066015 and fish intake frequency was substantially attenuated. Subgroup analysis revealed that the effect of the 12q24 variant on fish intake frequency was stronger in males than in females (P for interaction = 0.007) and stronger in the older subgroup than in the younger subgroup (P for interaction = 0.006).
- : Genes and Nutrition
- : https://genesandnutrition.biomedcentral.com/articles/10.1186/s12263-019-0646-6