May 26, 2017

Akabane (AKAV) and Schmallenberg (SBV) viruses are Orthobunyavirus transmitted by arthropod vectors with a broad cellular tropism in vitro as well as in vivo. AKAV and SBV are the etiological agents of arthrogryposis-hydranencephaly syndrome in ruminants, which causes considerable economic losses in the livestock industry. Here, we identified heparan sulfate proteoglycan as a major cellular attachment factor for the entry of AKAV and SBV. ……

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Paper Information

 Shin Murakami*1, Akiko Takenaka-Uema*1, Tomoya Kobayashi*1 , Masayuki Shimojima*2 , Kentaro Kato*1*3, Massimo Palmarinie*4 , Taisuke Horimoto*1

Author Affiliations
 *1 Graduate School of Agricultural and Life Sciences,The University of Tokyo, Tokyo,Japan
 *2 National Research Center for Protozoan Diseases, Tokyo, Japan
 *3 Obihiro University of Agriculture and Veterinary Medicine,Obihiro, Japan
 *4 MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom